Keppra (Levetiracetam) is a popular anticonvulsant and here we give information about Keppra and tips where to buy Generic Keppra online for a cheap price! Dilantin is a good alternative for Keppra and much cheaper or read about all medications available with in depth information.
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How does Keppra actually work?
Levetiracetam is an antiepileptic drug (AED) commonly used to treat epilepsy. While its precise mechanism of action is not fully understood, several theories suggest its involvement in modulating neurotransmitter release, particularly the release of the inhibitory neurotransmitter gamma-aminobutyric acid (GABA). Here is an overview of how Keppra is believed to work:
1. Binding to Synaptic Vesicle Protein 2A (SV2A):
- Location: Keppra is thought to exert its primary effects by binding to synaptic vesicle protein 2A (SV2A), a protein involved in the regulation of neurotransmitter release.
- Prospective Target: SV2A is widely distributed in the brain, especially in regions involved in seizure activity.
2. Modulation of Neurotransmitter Release:
- Effect: By binding to SV2A, Keppra is believed to modulate neurotransmitter release, influencing the release of various neurotransmitters, including GABA.
- Prospective Role: This modulation of neurotransmitter release may contribute to the antiepileptic effects of Keppra.
3. GABAergic System Modulation:
- Effect: While not a direct agonist or antagonist of GABA receptors, Keppra’s influence on SV2A may indirectly affect the GABAergic system.
- Prospective Role: GABA is the primary inhibitory neurotransmitter in the brain, and enhancing its effects can contribute to the suppression of excessive neuronal activity associated with seizures.
4. Limited Impact on Other Receptors:
- Effect: Keppra’s effects are believed to be relatively selective, with limited impact on other neurotransmitter systems.
- Prospective Role: This selectivity may contribute to a favorable side effect profile compared to some other antiepileptic drugs.
Clinical Applications of Keppra:
- Prospective Role: Keppra is primarily indicated for the treatment of partial-onset seizures in adults and children, myoclonic seizures in juvenile myoclonic epilepsy, and primary generalized tonic-clonic seizures.
2. Adjunctive Therapy:
- Prospective Role: Keppra is often used as adjunctive therapy, meaning it is prescribed alongside other antiepileptic medications to enhance seizure control.
Pharmacokinetics:
1. Rapid Absorption and Distribution:
- Prospective Role: Keppra is known for its rapid absorption and distribution, leading to a relatively quick onset of action.
2. Renal Excretion:
- Prospective Role: The drug is primarily excreted unchanged through the kidneys, making renal function an important consideration in dosing.
Conclusion:
While the exact mechanisms of Keppra’s antiepileptic effects are not fully elucidated, its association with SV2A and potential modulation of neurotransmitter release, particularly in the GABAergic system, suggest a complex but targeted approach to seizure control. Keppra’s clinical applications in epilepsy treatment and its favorable pharmacokinetic profile contribute to its widespread use as a valuable option in the management of seizure disorders. As ongoing research deepens our understanding of its mechanisms, Keppra’s role in epilepsy care may continue to evolve, offering hope and improved seizure management for individuals affected by epilepsy.